Protein Changes Contributing to Right Ventricular Cardiomyocyte Diastolic Dysfunction in Pulmonary Arterial Hypertension

BACKGROUND: Right ventricular (RV) diastolic function is impaired in patients with pulmonary arterial hypertension (PAH). Our previous study showed that elevated cardiomyocyte stiffness and myofilament Ca(2+) sensitivity underlie diastolic dysfunction in PAH. This study investigates protein modifica...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Rain, Silvia, Bos, Denielli da Silva Goncalves, Handoko, M. Louis, Westerhof, Nico, Stienen, Ger, Ottenheijm, Coen, Goebel, Max, Dorfmüller, Peter, Guignabert, Christophe, Humbert, Marc, Bogaard, Harm‐Jan, dos Remedios, Cris, Saripalli, Chandra, Hidalgo, Carlos G., Granzier, Henk L., Vonk‐Noordegraaf, Anton, van der Velden, Jolanda, de Man, Frances S.
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4309054/
https://ncbi.nlm.nih.gov/pubmed/24895160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000716
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