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An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation
V(D)J recombination is initiated by a specialized transposase consisting of the subunits RAG-1 and RAG-2. The susceptibility of gene segments to DNA cleavage by the V(D)J recombinase is correlated with epigenetic modifications characteristic of active chromatin, including trimethylation of histone H...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4308961/ https://ncbi.nlm.nih.gov/pubmed/25543141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.12.001 |
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