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A PHD FINGER DOMAIN IN RAG-2 THAT BINDS HYPERMETHYLATED LYSINE 4 OF HISTONE H3 IS NECESSARY FOR EFFICIENT V(D)J REARRANGEMENT

V(D)J recombination is initiated by a specialized transposase consisting of RAG-1 and RAG-2. The ability of antigen receptor gene segments to undergo V(D)J recombination is correlated with spatially- and temporally-restricted chromatin modifications. We have found that RAG-2 binds specifically to hi...

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Detalhes bibliográficos
Main Authors: Liu, Yun, Subrahmanyam, Ramesh, Chakraborty, Tirtha, Sen, Ranjan, Desiderio, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711682/
https://ncbi.nlm.nih.gov/pubmed/17936034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.09.005
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