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Relative conformational rigidity in oxytocin and (1-penicillamine)-oxytocin: a proposal for the relationship of conformational flexibility to peptide hormone agonism and antagonism.

A comparative study of the proton and carbon-13 nuclear magnetic resonance spectral parameters of the peptide hormone oxytocin and of its competitive inhibitor [1-L-penicillamine]oxytocin has been made, and the results analyzed in terms of comparative conformational and dynamic properties. The resul...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Meraldi, J P, Hruby, V J, Brewster, A I
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 1977
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Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC430763/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/266179/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.74.4.1373
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