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Using inactivating mutations to provide insight into drug action
The role of ezetimibe in lowering plasma cholesterol has been established; however, controversy remains about its clinical benefit. A recent study utilizes naturally occurring genetic variation within the NPC1-like 1 gene (NPC1L1) to demonstrate the potential for pharmacologic inhibition of the prot...
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| Publicat a: | Genome Med |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4307143/ https://ncbi.nlm.nih.gov/pubmed/25628760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0130-x |
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