Activation of p53 with Ilimaquinone and Ethylsmenoquinone, Marine Sponge Metabolites, Induces Apoptosis and Autophagy in Colon Cancer Cells

The tumor suppressor, p53, plays an essential role in the cellular response to stress through regulating the expression of genes involved in cell cycle arrest, apoptosis and autophagy. Here, we used a cell-based reporter system for the detection of p53 response transcription to identify the marine s...

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Vydáno v:Mar Drugs
Hlavní autoři: Lee, Hyun-Young, Chung, Kyu Jin, Hwang, In Hyun, Gwak, Jungsuk, Park, Seoyoung, Ju, Bong Gun, Yun, Eunju, Kim, Dong-Eun, Chung, Young-Hwa, Na, MinKyun, Song, Gyu-Yong, Oh, Sangtaek
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306951/
https://ncbi.nlm.nih.gov/pubmed/25603347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md13010543
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