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A surface plasmon resonance approach to monitor toxin interactions with an isolated voltage-gated sodium channel paddle motif
Animal toxins that inhibit voltage-gated sodium (Na(v)) channel fast inactivation can do so through an interaction with the S3b–S4 helix-turn-helix region, or paddle motif, located in the domain IV voltage sensor. Here, we used surface plasmon resonance (SPR), an optical approach that uses polarized...
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| Pubblicato in: | J Gen Physiol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4306711/ https://ncbi.nlm.nih.gov/pubmed/25624450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201411268 |
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