Hepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation

Hepatic steatosis is associated with detrimental metabolic phenotypes including enhanced risk for diabetes. Stearoyl-CoA desaturases (SCDs) catalyze the synthesis of MUFAs. In mice, genetic ablation of SCDs reduces hepatic de novo lipogenesis (DNL) and protects against diet-induced hepatic steatosis...

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Veröffentlicht in:J Lipid Res
Hauptverfasser: Burhans, Maggie S., Flowers, Matthew T., Harrington, Kristin R., Bond, Laura M., Guo, Chang-An, Anderson, Rozalyn M., Ntambi, James M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306685/
https://ncbi.nlm.nih.gov/pubmed/25555387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M054429
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