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Proteome-wide analysis of human disease mutations in short linear motifs: neglected players in cancer?

Disease mutations are traditionally thought to impair protein functionality by disrupting the folded globular structure of proteins. However, 22% of human disease mutations occur in natively unstructured segments of proteins known as intrinsically disordered regions (IDRs). This therefore implicates...

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Detalhes bibliográficos
Publicado no:Mol Biosyst
Main Authors: Uyar, Bora, Weatheritt, Robert J., Dinkel, Holger, Davey, Norman E., Gibson, Toby J.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306509/
https://ncbi.nlm.nih.gov/pubmed/25057855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4mb00290c
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