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Proteome-wide analysis of human disease mutations in short linear motifs: neglected players in cancer?
Disease mutations are traditionally thought to impair protein functionality by disrupting the folded globular structure of proteins. However, 22% of human disease mutations occur in natively unstructured segments of proteins known as intrinsically disordered regions (IDRs). This therefore implicates...
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| Publicat a: | Mol Biosyst |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Royal Society of Chemistry
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4306509/ https://ncbi.nlm.nih.gov/pubmed/25057855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4mb00290c |
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