The First Small-Molecule Inhibitors of Members of the Ribonuclease E Family

The Escherichia coli endoribonuclease RNase E is central to the processing and degradation of all types of RNA and as such is a pleotropic regulator of gene expression. It is essential for growth and was one of the first examples of an endonuclease that can recognise the 5′-monophosphorylated ends o...

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Udgivet i:Sci Rep
Main Authors: Kime, Louise, Vincent, Helen A., Gendoo, Deena M. A., Jourdan, Stefanie S., Fishwick, Colin W. G., Callaghan, Anastasia J., McDowall, Kenneth J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306137/
https://ncbi.nlm.nih.gov/pubmed/25619596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08028
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