Treatment-related Hypertension as a Pharmacodynamic Biomarker for the Efficacy of Bevacizumab in Advanced Pancreas Cancer: A Pooled Analysis of 4 Prospective Trials of Gemcitabine-based Therapy With Bevacizumab

PURPOSE: Phase III studies of bevacizumab in advanced pancreas cancer (APCA) demonstrated no improvement in outcome. No validated biomarkers for bevacizumab efficacy exist. We evaluated bevacizumab-related hypertension (B-HTN) as a biomarker in APCA patients in a pooled analysis from 4 prospective c...

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Veröffentlicht in:Am J Clin Oncol
Hauptverfasser: Pant, Shubham, Martin, Ludmila K., Geyer, Susan, Wei, Lai, Van Loon, Katherine, Sommovilla, Nili, Zalupski, Mark, Iyer, Renuka, Fogelman, David, Ko, Andrew H., Bekaii-Saab, Tanios
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4305484/
https://ncbi.nlm.nih.gov/pubmed/25068471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/COC.0000000000000108
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