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Hybridization of RNA to double-stranded DNA: formation of R-loops.
RNA can hybridize to double-stranded DNA in the presence of 70% formamide by displacing the identical DNA strand. The resulting structure, called an R-loop, is formed in formamide probably because of the greater thermodynamic stability of the RNA-DNA hybrid when it is near the denaturation temperatu...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1976
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC430535/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/781674/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.73.7.2294 |
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