Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity

Germline variation at immunoglobulin (IG) loci is critical for pathogen-mediated immunity, but establishing complete haplotype sequences in these regions has been problematic because of complex sequence architecture and diploid source DNA. We sequenced BAC clones from the effectively haploid human h...

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Veröffentlicht in:Genes Immun
Hauptverfasser: Watson, C T, Steinberg, K M, Graves, T A, Warren, R L, Malig, M, Schein, J, Wilson, R K, Holt, R A, Eichler, E E, Breden, F
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304971/
https://ncbi.nlm.nih.gov/pubmed/25338678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2014.56
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