Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity

Germline variation at immunoglobulin (IG) loci is critical for pathogen-mediated immunity, but establishing complete haplotype sequences in these regions has been problematic because of complex sequence architecture and diploid source DNA. We sequenced BAC clones from the effectively haploid human h...

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Detalhes bibliográficos
Publicado no:Genes Immun
Main Authors: Watson, C T, Steinberg, K M, Graves, T A, Warren, R L, Malig, M, Schein, J, Wilson, R K, Holt, R A, Eichler, E E, Breden, F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304971/
https://ncbi.nlm.nih.gov/pubmed/25338678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gene.2014.56
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