Cold–inducible Zfp516 Activates UCP1 Transcription to Promote Browning of White Fat and Development of Brown Fat

Uncoupling protein 1 (UCP1) mediates non-shivering thermogenesis and, upon cold exposure, is induced in BAT and subcutaneous white adipose tissue (iWAT). Here, by high-throughput screening using the UCP1 promoter, we identify Zfp516 as a novel transcriptional activator of UCP1 as well as PGC1α there...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Dempersmier, Jon, Sambeat, Audrey, Gulyaeva, Olga, Paul, Sarah M., Hudak, Carolyn S.S., Raposo, Helena F., Kwan, Hiu-Yee, Kang, Chulho, Wong, Roger H. F., Sul, Hei Sook
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304950/
https://ncbi.nlm.nih.gov/pubmed/25578880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.12.005
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