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HIV-1 Tat activates a RhoA signaling pathway to reduce NMDA-evoked calcium responses in hippocampal neurons via an actin-dependent mechanism
HIV-associated neurocognitive disorders (HAND) afflict approximately half of HIVinfected patients. HIV-infected cells within the CNS release neurotoxic viral proteins such as the transactivator of transcription (Tat). Tat caused a biphasic change in NMDAR function; NMDA-evoked increases in intracell...
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| Publicado no: | J Neurochem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4304915/ https://ncbi.nlm.nih.gov/pubmed/25156524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12936 |
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