TLR3 Signaling in Macrophages Is Indispensable for the Protective Immunity of Invariant Natural Killer T Cells against Enterovirus 71 Infection

Enterovirus 71 (EV71) is the most virulent pathogen among enteroviruses that cause hand, foot and mouth disease in children but rarely in adults. The mechanisms that determine the age-dependent susceptibility remain largely unclear. Here, we found that the paucity of invariant natural killer T (iNKT...

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Vydáno v:PLoS Pathog
Hlavní autoři: Zhu, Kai, Yang, Juhao, Luo, Kaiming, Yang, Chunhui, Zhang, Na, Xu, Ruifeng, Chen, Jianxia, Jin, Mingfei, Xu, Bin, Guo, Nining, Wang, Jianrong, Chen, Zuolong, Cui, Ying, Zhao, Hui, Wang, Yan, Deng, Chaoyang, Bai, Li, Ge, Baoxue, Qin, Cheng-Feng, Shen, Hao, Yang, Chun-Fu, Leng, Qibin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304831/
https://ncbi.nlm.nih.gov/pubmed/25615690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004613
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