Host Genetic Variants in the Interleukin-6 Promoter Predict Poor Outcome in Patients with Estrogen Receptor-Positive, Node-Positive Breast Cancer

Interleukin-6 (IL-6) modulates immune response, estrogen production and growth pathways in breast cancer. We evaluated the effect of several common, functional IL-6 promoter variants in node-positive breast cancer patients enrolled on a multicenter, cooperative group, adjuvant chemotherapy trial to...

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Udgivet i:Cancer Res
Main Authors: DeMichele, Angela, Gray, Robert, Horn, Michelle, Chen, Jinbo, Aplenc, Richard, Vaughan, William P., Tallman, Martin S.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304767/
https://ncbi.nlm.nih.gov/pubmed/19435922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2989
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