Pharmacokinetics, Pharmacodynamics, and Safety of Peginterferon Beta-Ia in Subjects with Normal or Impaired Renal Function

Peginterferon beta-1a was efficacious in a Phase 3 relapsing multiple sclerosis trial, and its safety profile was consistent with other beta interferons. This study evaluated the impact of renal impairment on the pharmacokinetics and pharmacodynamics (neopterin elevation; a biomarker of pharmacologi...

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Bibliographic Details
Published in:J Clin Pharmacol
Main Authors: Hu, Xiao, Seddighzadeh, Ali, Stecher, Scott, Zhu, Ying, Goyal, Jaya, Matson, Mark, Marbury, Thomas, Smith, William, Nestorov, Ivan, Hung, Serena
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
Subjects:
Special Populations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303928/
https://ncbi.nlm.nih.gov/pubmed/25187030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.390
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