Loss of Epithelial p53 and αv Integrin Cooperate through Akt to Induce Squamous Cell Carcinoma yet Prevent Remodeling of the Tumor Microenvironment

Most of the squamous cell carcinomas (SCCs) of the skin and head and neck contain p53 mutations. The presence of p53 mutations in premalignant lesions suggests that they represent early events during tumor progression and additional alterations may be required for SCC development. Here we show that...

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Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: Savar, Aaron, Acin, Sergio, Gonzalez, Cassandra L., El-Sawy, Tarek, Mejia, Olga, Li, Zhongyou, Esmaeli, Bita, Lacy-Hulbert, Adam, El-Naggar, Adel, McCarty, Joseph H., Caulin, Carlos
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303549/
https://ncbi.nlm.nih.gov/pubmed/24469034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.585
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