Human pituitary growth hormone: restoration of full biological activity by noncovalent interaction of two fragments of the hormone.
The NH2-terminal 134 amino-acid fragment of the reduced-carbamidomethylated human somatropin molecule is found to react noncovalently with the COOH-terminal 51 amino-acid fragment in solutions of pH 8.4 at 2 degrees to restore full biological activity as evidenced by the rat tibia and pigeon crop-sa...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1976
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC430319/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/58417/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.73.5.1476 |
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