Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway

INTRODUCTION: Obesity is a known risk factor for breast cancer. Sphingosine kinase 1 (SK1) is an oncogenic lipid kinase that is overexpressed in breast tumours and linked with poor prognosis, however, its role in obesity-driven breast cancer was never elucidated. METHODS: Human primary and secondary...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Breast Cancer Res
मुख्य लेखकों: Alshaker, Heba, Krell, Jonathan, Frampton, Adam E, Waxman, Jonathan, Blyuss, Oleg, Zaikin, Alexey, Winkler, Mathias, Stebbing, Justin, Yagüe, Ernesto, Pchejetski, Dmitri
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BioMed Central 2014
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303110/
https://ncbi.nlm.nih.gov/pubmed/25482303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-014-0426-6
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