Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway

INTRODUCTION: Obesity is a known risk factor for breast cancer. Sphingosine kinase 1 (SK1) is an oncogenic lipid kinase that is overexpressed in breast tumours and linked with poor prognosis, however, its role in obesity-driven breast cancer was never elucidated. METHODS: Human primary and secondary...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res
Main Authors: Alshaker, Heba, Krell, Jonathan, Frampton, Adam E, Waxman, Jonathan, Blyuss, Oleg, Zaikin, Alexey, Winkler, Mathias, Stebbing, Justin, Yagüe, Ernesto, Pchejetski, Dmitri
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303110/
https://ncbi.nlm.nih.gov/pubmed/25482303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-014-0426-6
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