Global O-GlcNAc Levels Modulate Transcription of the Adipocyte Secretome during Chronic Insulin Resistance

Increased flux through the hexosamine biosynthetic pathway and the corresponding increase in intracellular glycosylation of proteins via O-linked β-N-acetylglucosamine (O-GlcNAc) is sufficient to induce insulin resistance (IR) in multiple systems. Previously, our group used shotgun proteomics to ide...

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Detalles Bibliográficos
Publicado en:Front Endocrinol (Lausanne)
Autores principales: Wollaston-Hayden, Edith E., Harris, Ruth B. S., Liu, Bingqiang, Bridger, Robert, Xu, Ying, Wells, Lance
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2015
Materias:
Endocrinology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302944/
https://ncbi.nlm.nih.gov/pubmed/25657638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2014.00223
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