Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature

Maintenance of vascular integrity is required for embryogenesis and organ homeostasis. However, the gene expression programs that stabilize blood vessels are poorly understood. Here, we show that the histone methyltransferase Ezh2 maintains integrity of the developing vasculature by repressing a tra...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Delgado-Olguín, Paul, Dang, Lan T., He, Daniel, Thomas, Sean, Chi, Lijun, Sukonnik, Tatyana, Khyzha, Nadiya, Dobenecker, Marc-Werner, Fish, Jason E., Bruneau, Benoit G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302930/
https://ncbi.nlm.nih.gov/pubmed/25359725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.112607
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