Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature

Maintenance of vascular integrity is required for embryogenesis and organ homeostasis. However, the gene expression programs that stabilize blood vessels are poorly understood. Here, we show that the histone methyltransferase Ezh2 maintains integrity of the developing vasculature by repressing a tra...

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Dettagli Bibliografici
Pubblicato in:Development
Autori principali: Delgado-Olguín, Paul, Dang, Lan T., He, Daniel, Thomas, Sean, Chi, Lijun, Sukonnik, Tatyana, Khyzha, Nadiya, Dobenecker, Marc-Werner, Fish, Jason E., Bruneau, Benoit G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists 2014
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302930/
https://ncbi.nlm.nih.gov/pubmed/25359725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.112607
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