Spermine reverses lipopolysaccharide-induced memory deficit in mice

BACKGROUND: Lipopolysaccharide (LPS) induces neuroinflammation and memory deficit. Since polyamines improve memory in various cognitive tasks, we hypothesized that spermine administration reverses LPS-induced memory deficits in an object recognition task in mice. The involvement of the polyamine bin...

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Bibliografiske detaljer
Udgivet i:J Neuroinflammation
Main Authors: Frühauf, Pâmella Karina Santana, Porto Ineu, Rafael, Tomazi, Lediane, Duarte, Thiago, Mello, Carlos Fernando, Rubin, Maribel Antonello
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4302583/
https://ncbi.nlm.nih.gov/pubmed/25573647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-014-0220-5
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