Direct experimental evidence for kinetic proofreading in amino acylation of tRNAIle.

Kinetic proofreading is a reaction scheme with a structure more complicated than that of Michaelis kinetics, which leads to a proofreading for errors in the recognition of a correct substrate by an enzyme. We have measured the stoichiometry between ATP hydrolysis and tRNAIle charging, using the enzy...

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Bibliographic Details
Main Authors: Hopfield, J J, Yamane, T, Yue, V, Coutts, S M
Format: Artigo
Language:Inglês
Published: 1976
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC430221/
https://ncbi.nlm.nih.gov/pubmed/1063397
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