The effects of CCR5 inhibition on regulatory T-cell recruitment to colorectal cancer

BACKGROUND: Regulatory T cells (Treg) are enriched in human colorectal cancer (CRC) where they suppress anti-tumour immunity. The chemokine receptor CCR5 has been implicated in the recruitment of Treg from blood into CRC and tumour growth is delayed in CCR5−/− mice, associated with reduced tumour Tr...

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Enregistré dans:
Détails bibliographiques
Publié dans:Br J Cancer
Auteurs principaux: Ward, S T, Li, K K, Hepburn, E, Weston, C J, Curbishley, S M, Reynolds, G M, Hejmadi, R K, Bicknell, R, Eksteen, B, Ismail, T, Rot, A, Adams, D H
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
Sujets:
Translational Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301825/
https://ncbi.nlm.nih.gov/pubmed/25405854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.572
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