Panspecies Small-Molecule Disruptors of Heterochromatin-Mediated Transcriptional Gene Silencing

Heterochromatin underpins gene repression, genome integrity, and chromosome segregation. In the fission yeast Schizosaccharomyces pombe, conserved protein complexes effect heterochromatin formation via RNA interference-mediated recruitment of a histone H3 lysine 9 methyltransferase to cognate chroma...

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Publicado no:Mol Cell Biol
Main Authors: Castonguay, Emilie, White, Sharon A., Kagansky, Alexander, St-Cyr, Daniel J., Castillo, Araceli G., Brugger, Christiane, White, Rachel, Bonilla, Carolina, Spitzer, Michaela, Earnshaw, William C., Schalch, Thomas, Ekwall, Karl, Tyers, Mike, Allshire, Robin C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301722/
https://ncbi.nlm.nih.gov/pubmed/25487573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01102-14
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