Spinal blockage of P/Q- or N-type voltage-gated calcium channels modulates functional and symptomatic changes related to haemorrhagic cystitis in mice

BACKGROUND AND PURPOSE: Spinal voltage-gated calcium channels (VGCCs) are pivotal regulators of painful and inflammatory alterations, representing attractive therapeutic targets. We examined the effects of epidural administration of the P/Q- and N-type VGCC blockers Tx3-3 and Phα1β, respectively, is...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Silva, R B M, Sperotto, N D M, Andrade, E L, Pereira, T C B, Leite, C E, de Souza, A H, Bogo, M R, Morrone, F B, Gomez, M V, Campos, M M
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301699/
https://ncbi.nlm.nih.gov/pubmed/25298144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12966
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