Persistent Hepatitis C Virus Infection Impairs Ribavirin Antiviral Activity through Clathrin-Mediated Trafficking of Equilibrative Nucleoside Transporter 1

Ribavirin (RBV) continues to be an important component of interferon-free hepatitis C treatment regimens, as RBV alone does not inhibit hepatitis C virus (HCV) replication effectively; the reason for this ineffectiveness has not been established. In this study, we investigated the RBV resistance mec...

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Udgivet i:J Virol
Main Authors: Panigrahi, Rajesh, Chandra, Partha K., Ferraris, Pauline, Kurt, Ramazan, Song, Kyoungsub, Garry, Robert F., Reiss, Krzysztof, Coe, Imogen R., Furihata, Tomomi, Balart, Luis A., Wu, Tong, Dash, Srikanta
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301154/
https://ncbi.nlm.nih.gov/pubmed/25339775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02492-14
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