Identification of the Physiological Gene Targets of the Essential Lytic Replicative Kaposi's Sarcoma-Associated Herpesvirus ORF57 Protein

The Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 gene product is essential for lytic KSHV replication and virion production. Recombinant ORF57-null mutants fail to accumulate several lytic cycle mRNAs at wild-type levels, leading to decreased production of lytic proteins necessary for e...

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Bibliographic Details
Published in:J Virol
Main Authors: Verma, Dinesh, Li, Da-Jiang, Krueger, Brian, Renne, Rolf, Swaminathan, Sankar
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300733/
https://ncbi.nlm.nih.gov/pubmed/25410858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02663-14
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