T-cell–restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung

Although overexpression of T-bet, a master transcription factor in type-1 helper T lymphocytes, has been reported in several hematologic and immune diseases, its role in their pathogenesis is not fully understood. In the present study, we used transgenic model mice (T-bet(tg/wt) and T-bet(tg/tg)) to...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Iriguchi, Shoichi, Kikuchi, Norihiro, Kaneko, Shin, Noguchi, Emiko, Morishima, Yuko, Matsuyama, Masashi, Yoh, Keigyou, Takahashi, Satoru, Nakauchi, Hiromitsu, Ishii, Yukio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2015
Konular:
Phagocytes, Granulocytes, and Myelopoiesis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300389/
https://ncbi.nlm.nih.gov/pubmed/25349175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-575225
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