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The Good, the Bad, and the Ugly: in search of gold standards for assessing functional genetic screen quality

Variable screen quality, off-target effects, and unclear false discovery rates often hamper large-scale functional genomic screens in mammalian cells. Hart et al (2014) introduce gold standard reference sets of essential and non-essential genes, aiming at standardizing the analysis of genome-wide sc...

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Vydáno v:Mol Syst Biol
Hlavní autoři: Evers, Bastiaan, Bernards, Rene, Beijersbergen, Roderick L
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299495/
https://ncbi.nlm.nih.gov/pubmed/24987117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20145372
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