Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.

We inactivated the mouse metallothionein (MT)-I and MT-II genes in embryonic stem cells and generated mice homozygous for these mutant alleles. These mice were viable and reproduced normally when reared under normal laboratory conditions. They were, however, more susceptible to hepatic poisoning by...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Masters, B A, Kelly, E J, Quaife, C J, Brinster, R L, Palmiter, R D
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1994
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42993/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8290567/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.2.584
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