Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.

We inactivated the mouse metallothionein (MT)-I and MT-II genes in embryonic stem cells and generated mice homozygous for these mutant alleles. These mice were viable and reproduced normally when reared under normal laboratory conditions. They were, however, more susceptible to hepatic poisoning by...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Masters, B A, Kelly, E J, Quaife, C J, Brinster, R L, Palmiter, R D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42993/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8290567/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.2.584
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