Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.

We inactivated the mouse metallothionein (MT)-I and MT-II genes in embryonic stem cells and generated mice homozygous for these mutant alleles. These mice were viable and reproduced normally when reared under normal laboratory conditions. They were, however, more susceptible to hepatic poisoning by...

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Hauptverfasser: Masters, B A, Kelly, E J, Quaife, C J, Brinster, R L, Palmiter, R D
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC42993/
https://ncbi.nlm.nih.gov/pubmed/8290567
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