Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.

We inactivated the mouse metallothionein (MT)-I and MT-II genes in embryonic stem cells and generated mice homozygous for these mutant alleles. These mice were viable and reproduced normally when reared under normal laboratory conditions. They were, however, more susceptible to hepatic poisoning by...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Masters, B A, Kelly, E J, Quaife, C J, Brinster, R L, Palmiter, R D
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42993/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8290567/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.2.584
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