Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast

The pluripotent mammalian epiblast undergoes unusually fast cell proliferation. This rapid growth is expected to generate a high transcriptional demand, but the underlying mechanisms remain unknown. We show here that the chromatin remodeler Chd1 is required for transcriptional output and development...

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Dades bibliogràfiques
Publicat a:Development
Autors principals: Guzman-Ayala, Marcela, Sachs, Michael, Koh, Fong Ming, Onodera, Courtney, Bulut-Karslioglu, Aydan, Lin, Chih-Jen, Wong, Priscilla, Nitta, Rachel, Song, Jun S., Ramalho-Santos, Miguel
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists 2015
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299150/
https://ncbi.nlm.nih.gov/pubmed/25480920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.114843
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