In Vivo Microdialysis Reveals Age-Dependent Decrease of Brain Interstitial Fluid Tau Levels in P301S Human Tau Transgenic Mice

Although tau is a cytoplasmic protein, it is also found in brain extracellular fluids, e.g., CSF. Recent findings suggest that aggregated tau can be transferred between cells and extracellular tau aggregates might mediate spread of tau pathology. Despite these data, details of whether tau is normall...

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Vydáno v:J Neurosci
Hlavní autoři: Yamada, Kaoru, Cirrito, John R., Stewart, Floy R., Jiang, Hong, Finn, Mary Beth, Holmes, Brandon B., Binder, Lester I., Mandelkow, Eva-Maria, Diamond, Marc I., Lee, Virginia M.-Y., Holtzman, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4299126/
https://ncbi.nlm.nih.gov/pubmed/21917794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2569-11.2011
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