Physiological and genetic analysis of multiple sodium channel variants in a model of genetic absence epilepsy

In excitatory neurons, SCN2A (Na(V)1.2) and SCN8A (Na(V)1.6) sodium channels are enriched at the axon initial segment. Na(V)1.6 is implicated in several mouse models of absence epilepsy, including a missense mutation identified in a chemical mutagenesis screen (Scn8a(V929F)). Here, we confirmed the...

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Vydáno v:Neurobiol Dis
Hlavní autoři: Oliva, M K, McGarr, T C, Beyer, B J, Gazina, E, Kaplan, D I, Cordeiro, L, Thomas, E, Dib-Hajj, S D, Waxman, S G, Frankel, W N, Petrou, S
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298829/
https://ncbi.nlm.nih.gov/pubmed/24657915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.03.007
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