Anti-mouse CD52 monoclonal antibody ameliorates intestinal epithelial barrier function in interleukin-10 knockout mice with spontaneous chronic colitis

Intestinal inflammation causes tight junction changes and death of epithelial cells, and plays an important role in the development of Crohn*s disease (CD). CD52 monoclonal antibody (CD52 mAb) directly targets the cell surface CD52 and is effective in depleting mature lymphocytes by cytolytic effect...

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Detalhes bibliográficos
Publicado no:Immunology
Main Authors: Wang, Honggang, Dong, Jianning, Shi, Peiliang, Liu, Jianhui, Zuo, Lugen, Li, Yi, Gong, Jianfeng, Gu, Lili, Zhao, Jie, Zhang, Liang, Zhang, Wei, Zhu, Weiming, Li, Ning, Li, Jieshou
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298419/
https://ncbi.nlm.nih.gov/pubmed/25087772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12366
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