Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer

Poly (ADP) ribose polymerase (PARP) plays a key role in DNA repair and is highly expressed in small cell lung cancer (SCLC). We investigated the therapeutic impact of PARP inhibition in SCLC. In vitro cytotoxicity of veliparib, cisplatin, carboplatin, and etoposide singly and combined was determined...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Owonikoko, Taofeek K, Zhang, Guojing, Deng, Xingming, Rossi, Michael R, Switchenko, Jeffrey M, Doho, Gregory H, Chen, Zhengjia, Kim, Sungjin, Strychor, Sandy, Christner, Susan M, Beumer, Jan, Li, Chunyang, Yue, Ping, Chen, Alice, Sica, Gabriel L, Ramalingam, Suresh S, Kowalski, Jeanne, Khuri, Fadlo R, Sun, Shi-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298385/
https://ncbi.nlm.nih.gov/pubmed/25124282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.317
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