Functional Role of Serotonin in Insulin Secretion in a Diet-Induced Insulin-Resistant State

The physiological role of serotonin, or 5-hydroxytryptamine (5-HT), in pancreatic β-cell function was previously elucidated using a pregnant mouse model. During pregnancy, 5-HT increases β-cell proliferation and glucose-stimulated insulin secretion (GSIS) through the Gα(q)-coupled 5-HT2b receptor (H...

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Détails bibliographiques
Publié dans:Endocrinology
Auteurs principaux: Kim, Kyuho, Oh, Chang-Myung, Ohara-Imaizumi, Mica, Park, Sangkyu, Namkung, Jun, Yadav, Vijay K., Tamarina, Natalia A., Roe, Michael W., Philipson, Louis H., Karsenty, Gerard, Nagamatsu, Shinya, German, Michael S., Kim, Hail
Format: Artigo
Langue:Inglês
Publié: Endocrine Society 2015
Sujets:
Diabetes-Insulin-Glucagon-Gastrointestinal
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298319/
https://ncbi.nlm.nih.gov/pubmed/25426873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1687
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