Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth

PTEN [phosphatidylinositol (3,4,5)-trisphosphate phosphatase and tensin homolog deleted from chromosome 10], a phosphatase and critical tumor suppressor, is regulated by numerous post-translational modifications, including phosphorylation, ubiquitination, acetylation, and SUMOylation, which affect P...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Li, Nan, Zhang, Yajie, Han, Xin, Liang, Ke, Wang, Jiadong, Feng, Lin, Wang, Wenqi, Songyang, Zhou, Lin, Chunru, Yang, Liuqing, Yu, Yonghao, Chen, Junjie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2015
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298135/
https://ncbi.nlm.nih.gov/pubmed/25547115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.251785.114
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