Novel recombinant chimeric virus-like particle is immunogenic and protective against both enterovirus 71 and coxsackievirus A16 in mice

Hand-foot-and-mouth disease (HFMD) has been recognized as an important global public health issue, which is predominantly caused by enterovirus 71 (EV-A71) and coxsackievirus A16 (CVA16). There is no available vaccine against HFMD. An ideal HFMD vaccine should be bivalent against both EV-A71 and CVA...

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Udgivet i:Sci Rep
Main Authors: Zhao, Hui, Li, Hao-Yang, Han, Jian-Feng, Deng, Yong-Qiang, Zhu, Shun-Ya, Li, Xiao-Feng, Yang, Hui-Qin, Li, Yue-Xiang, Zhang, Yu, Qin, E-De, Chen, Rong, Qin, Cheng-Feng
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297979/
https://ncbi.nlm.nih.gov/pubmed/25597595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07878
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