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Both rejection and tolerance of allografts can occur in the absence of secondary lymphoid tissues

In this study, we show that aly/aly mice, which are devoid of lymph nodes and Peyer’s patches, rejected acutely fully allogeneic skin and heart grafts. They mounted potent inflammatory direct alloresponses but failed to develop indirect alloreactivity after transplantation. Remarkably, skin allograf...

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Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Kant, Cavit D., Akiyama, Yoshinobu, Tanaka, Katsunori, Shea, Susan, Yamada, Yohei, Connolly, Sarah E, Marino, Jose, Tocco, Georges, Benichou, Gilles
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297718/
https://ncbi.nlm.nih.gov/pubmed/25535285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401157
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