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Concentrations of Trimethoprim-Sulfamethoxazole in Blood After a Single, Large Oral Dose

Concentrations of trimethoprim (TMP) and sulfamethoxazole (SMZ) in blood were determined in seven healthy volunteers after ingestion of 720 mg of TMP and 3,600 mg of SMZ (nine tablets of TMP-SMZ, 1:5 ratio) as a single oral dose. The mean levels of drug in blood achieved during the first 8 h after d...

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Autores principales: Yoshikawa, Thomas T., Guze, Lucien B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 1976
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC429771/
https://ncbi.nlm.nih.gov/pubmed/984788
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