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Highly Stable Aptamers Selected from a 2′-Fully Modified fGmH RNA Library for Targeting Biomaterials

When developed as targeting ligands for the in vivo delivery of biomaterials to biological systems, RNA aptamers immediately face numerous obstacles, in particular nuclease degradation and post-selection 2′ modification. This study aims to develop a novel class of highly stable, 2′-fully modified RN...

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Vydáno v:Biomaterials
Hlavní autoři: Friedman, Adam D., Kim, Dongwook, Liu, Rihe
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297552/
https://ncbi.nlm.nih.gov/pubmed/25443790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2014.08.046
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