Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer

PURPOSE: Cancer cells are highly dependent on folate metabolism, making them susceptible to drugs that inhibit folate receptor activities. Targeting overexpressed folate receptor alpha (FRα) in cancer cells offers a therapeutic opportunity. We investigated the functional mechanisms of MORAB-003 (far...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Wen, Yunfei, Graybill, Whitney S., Previs, Rebecca A., Hu, Wei, Ivan, Cristina, Mangala, Lingegowda S., Zand, Behrouz, Nick, Alpa M., Jennings, Nicholas B., Dalton, Heather J., Sehgal, Vasudha, Ram, Prahlad, Lee, Ju-Seog, Vivas-Mejia, Pablo E., Coleman, Robert L., Sood, Anil K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297546/
https://ncbi.nlm.nih.gov/pubmed/25416196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-1578
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