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Modulation of pain in pediatric sickle cell disease: understanding the balance between endothelin mediated vasoconstriction and apelin mediated vasodilation

Children with sickle cell disease (SCD) have painful vaso-occlusive episodes (VOE), which often reoccur across the individual's lifespan. Vaso-constrictive and vaso-dilatory molecules have been hypothesized to play a role in VOEs. Endothelin-1 (ET-1) is a potent vasoconstrictor that is released...

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Bibliografiske detaljer
Udgivet i:Blood Cells Mol Dis
Main Authors: Smith, Terika P., Schlenz, Alyssa M., Schatz, Jeffrey C., Maitra, Rangan, Sweitzer, Sarah M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297528/
https://ncbi.nlm.nih.gov/pubmed/25486928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2014.11.016
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